Recent clinical trials conducted by CESS in collaboration with the Regional Cancer Center, Trivandrum has shown that diffuse reflection spectroscopy (DRS) could turn out to be a highly sensitive tool to classify oral cavity tissues especially those of the tongue and lip that have poor classification sensitivities with laser-induced autofluorescence (LIAF). In this technique the DR ratio of oxygenated hemoglobin absorption

intensity at 545 and 575 nm is used to detect early tissue transformations associated with oral cavity cancer. This non-invasive diagnostic modality can go a long way in reducing the number of biopsies required to diagnose the grade of cancer correctly and in detecting oral pre-cancers thereby enhancing chances of cure and in improving the quality of life of patients.

The results of the study has appeared in – Rupananda Mallia et al, “Diffuse reflectance spectroscopy: An adjunct to autofluorescence spectroscopy in tongue cancer detection”, Applied Spectroscopy, 64(4), 409-418, 2010.

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